Featuring news, bio, rankings, playing activity, coach, stats, win-loss, points breakdown. We hypothesized that in the presence of excess chloride a palladate complex may form and promote the aza-Wacker oxidation, which would occur through an anti-Markovnikov selective trans-aminopalladation with the relatively large phthalimide nucleophile attacking the coordinated alkene to form the less hindered C–N bond. Official tennis player profile of Kamil Filali on the ATP Tour. While two different regioisomeric products are possible, unactivated alkenes undergo oxidative amination to afford the Markovnikov product – where the new C–N bond is formed at the more substituted carbon of the alkene. Further, it couples two easily accessible starting materials and, when O 2 is used as the oxidant, an equivalent of H 2O is the only byproduct. The oxidative amination of alkenes, also known as the aza-Wacker oxidation, is an excellent approach for the synthesis of a new C–N bond while simultaneously oxidizing the substrate and thus reestablishing an alkene for subsequent functionalization. Additionally, we have shown the regiodivergent hydrothiolation of allyl amines, where depending on the catalyst employed either the Markovnikov or anti-Markovnikov product is formed selectively.Īlthough directing groups are an excellent approach to promoting a regioselective hydrofunctionalization reaction, we are also interested in developing a catalyst controlled approach that does not rely on a prefunctionalized substrate. We have successfully demonstrated this strategy for the Markovnikov selective hydroamination of allyl imines and anti-Markovnikov selective hydroamination of homoallylic amines. Therefore the tether length, Lewis basic group, and catalyst can influence selectivity for either the Markovnikov or anti-Markovnikov product. Additionally, the Lewis basic group should direct the nucleometallation to form the favored metallacycle. First, the Lewis basic site binds to the metal, prior to functionalization of the olefin, and increases its concentration relative to the catalyst, promoting its coordination. Incorporation of this coordinating group has several advantages. Our initial efforts towards developing a selective hydrofunctionalization reaction utilize olefinic substrates bearing Lewis basic groups (L~C=C). Her scholarship focuses on enhancing individual functioning, belonging, and relationship outcomes among vulnerable, often marginalized, and traditionally.
Given this potential versatility and utility, the development of intermolecular, regio-, chemo-, and stereoselective hydrofunctionalization reactions represents an unmet need in synthetic chemistry. Gallus, Ph.D., LMFT, is an Associate Professor in Human Development and Family Science and Co-Director of the Institute for Developmental Disabilities at Oklahoma State University. The selective addition of X–H across a C=C multiple bond would allow for the single step installation of diverse functionalities from readily available starting materials.
Your browser does not support the audio element.Despite the prevalence of C–X (X = N, S, O) bonds in pharmaceuticals, their selective incorporation into organic compounds is often both time- and resource- consuming. Jade did her master’s in Machine Learning and is currently a Computer Science PhD candidate at EPFL in Lausanne, Switzerland. His PhD topic is “multi-task learning in diverse speech tasks” and it involves researching deep neural architectures which can be used for more than one speech task. Nik did his master’s in Computer Science and proceeded to do a PhD in Data Science at Radboud University in Nijmegen, The Netherlands. Nik Vaessen and Jade Cock finished their bachelor degrees at DKE and then went on to do their Master’s in KTH Royal Institute of Technology in Stockholm, Sweden. Philippe went on to do a PhD is at Wageningen University, and he’s working on fraud detection in financial markets. Kamil has advanced to pursue a PhD here in Maastricht University at the Swarmlab, he’s working on control and machine learning for cognitive robotics on insect farms. Kamil studied Artificial Intelligence and Philippe opted for Data Science for Decision Making. If you were ever thinking about doing a PhD, this is a perfect chance to ask questions about this decision! Join to discuss Master programmes, doing a PhD, PhD applications, various fields of research, companies, studying in Stockholm.īoth Kamil and Philippe have completed a bachelor’s and a master’s here in DKE. This Research+Industry Spotlight installment has 4 guests! They are all DKE alumni and PhD candidates in various universities.
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